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  • Title: Homocysteine and folate plasma concentrations in mother and baby at delivery after pre-eclamptic or normotensive pregnancy: Influence of parity.
    Author: Mistry HD, Mather J, Ramsay MM, Kurlak LO, Symonds ME, Broughton Pipkin F.
    Journal: Pregnancy Hypertens; 2011 Apr; 1(2):150-5. PubMed ID: 26104496.
    Abstract:
    UNLABELLED: Pre-eclampsia affects between 2% and 7% of all pregnant women, contributing to perinatal and maternal morbidity. There are conflicting data on plasma homocysteine and folate in pre-eclampsia, and little about fetal concentrations. OBJECTIVES: Firstly, to compare the concentrations of homocysteine and folate in maternal and paired fetal (umbilical venous) plasma samples from normotensive or pre-eclamptic pregnancies at delivery; secondly, to identify any effect of parity on these concentrations. STUDY DESIGN: Hospital based cross-sectional study consisting of 24 normotensive and 16 pre-eclamptic pregnant White European women from whom maternal and fetal plasma samples were collected at delivery. MAIN OUTCOME MEASURES: Maternal and fetal plasma homocysteine and folate concentrations between normotensive and pre-eclamptic pregnancies with varying parity. RESULTS: There were no significant differences in either maternal or fetal plasma homocysteine or folate concentrations between normotensive and pre-eclamptic pregnancies, or between homocysteine and folate. In both the normotensive and pre-eclamptic women, plasma folate concentration was higher in paired fetal compared to maternal plasma (P<0.001 and P=0.047, respectively). With regards to homocysteine, only the normotensive samples had higher fetal concentrations (P=0.002). Both maternal and fetal plasma folate concentrations were lower in parous women (P=0.001 and P=0.017, respectively), the lowest concentrations being in pre-eclamptic parous women (P=0.004), but homocysteine concentrations were similar (P>0.4 for both). CONCLUSIONS: The low plasma folate in parous women is an interesting finding and, when intake is also low, may contribute to adverse pregnancy outcomes, particularly in relation to pre-eclampsia.
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