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  • Title: Individual artery wall layer dimensions indicate increased cardiovascular risk in previous severe preeclampsia -an investigation using non-invasive high-frequency ultrasound.
    Author: Tansim A, Marita L, Anna-Karin W, Tord N.
    Journal: Pregnancy Hypertens; 2013 Apr; 3(2):66. PubMed ID: 26105857.
    Abstract:
    BACKGROUND: Preeclampsia (PE) is associated with increased risk for cardiovascular disease later in life. Studies using gold standard of non-invasive estimation of atherosclerosis, the common carotid artery intima-media-thickness (CCA-IMT), have not indicated increased atherosclerosis in women with previous PE. That reason may be that with increasing age and degree of atherosclerosis the intima increases, while the media decreases. OBJECTIVES: To assess whether the individual thickness of the CCA intima and media layers and calculation of intima/media (I/M) ratio indicate an increased cardiovascular risk in women with previous severe PE. METHOD: Arterial intima- and media tthicknesses were obtained by non-invasive high-frequency ultrasound (22MHz) in 42 women with previous severe PE and 44 women with previous normal pregnancies. RESULTS: Women with previous severe PE had a thicker mean CCA intima and a higher I/M ratio, compared to women with previous normal pregnancies (both p<0.0001). In ROC curve analysis, intima thickness and I/M ratio discriminated strongly with regard to previous severe PE. CONCLUSION: The method using individual estimation of the CCA intima and media layers and calculating the I/M ratio, clearly showed an increased degree of atherosclerosis in women with previous severe PE. This method might become a clinically useful tool to stratify cardiovascular risk, enabling early intervention and hopefully reduce their long-term cardiovascular risk.
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