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  • Title: [The hypothalamo-hypophyseal neurosecretory system in rats with hereditary arterial hypertension].
    Author: Iurisova MN, Markel' AL, Naumenko EV.
    Journal: Arkh Patol; 1989; 51(10):40-5. PubMed ID: 2610603.
    Abstract:
    Histochemical and cytometrical analysis of the peptidergic Gomori-positive or hypothalamo-hypophyseal neurosecretory system (HHNS) was made in the 3 strains of rats: spontaneously hypertensive rats (SHR), rats with inherited stress-induced arterial hypertension (ISIAH), and normotensive Wistar rats. A significant increase in the production of the peptide neurohormones by the supraoptic nuclei was found in two hypertensive strains (SHR and ISIAH) compared to the normotensive Wistar rats. For ISIAH-rats, the excretion of neurohormones was more pronounced in the region of median eminence, and for SHR--in the posterior hypophyseal lobe. It was concluded that hyperfunction of HHNS can play an important role in the hypertension development in two strains or rats studied.
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