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  • Title: [Necrotizing sarcoid-like granulomatous vasculitis of the lung in a female patient with liver cirrhosis].
    Author: Kogan EA, Drozdova AS.
    Journal: Arkh Patol; 1989; 51(10):63-7. PubMed ID: 2610608.
    Abstract:
    A case of necrotizing sarcoid-like granulomatous vasculitis (NSGV) in a female with liver cirrhosis (probably of virus etiology) complicated with systemic manifestations (skin vasculitis, syndromes of Raynaud and Sjögren). NSGV was diagnosed on the basis of the autopsy findings. Giant cell, epithelioid and macrophagal granulomas that differed from those in sarcoidosis by the presence of central necrosis, were found histologically in the walls of lung vessels and bronchi of various caliber. Keeping in mind a possible immuno-complexed pathogenesis of vasculitis in liver cirrhosis and NSGV as well as a probable viral etiology of liver cirrhosis it is likely that NSGV resulted from the vascular damage by immune complexes containing hepatitis virus antigens. Another peculiar feature of this observation was development of pulmonary hypertension.
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