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  • Title: In vivo treatment with erythroid differentiation factor (EDF/activin A) increases erythroid precursors (CFU-E and BFU-E) in mice.
    Author: Shiozaki M, Sakai R, Tabuchi M, Eto Y, Kosaka M, Shibai H.
    Journal: Biochem Biophys Res Commun; 1989 Dec 29; 165(3):1155-61. PubMed ID: 2610684.
    Abstract:
    The in vivo effect of human EDF on erythroid precursors (CFU-E and BFU-E) was investigated in normal and bled mice. In anemic (bled) mice, EDF treatment led to significant dose-dependent rises in the CFU-E and BFU-E levels of bone marrow. An elevation in the level of CFU-E was also seen in the spleen. In normal mice, a significant elevation in the level of bone marrow BFU-E was observed. Thus, EDF has an effect on erythropoiesis in anemic and normal mice in vivo.
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