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  • Title: Determination of Chromium, Selenium, and Molybdenum in Infant Formula and Adult Nutritional Products - Inductively Coupled Plasma-Mass Spectrometry: Collaborative Study, Final Action 2011.19.
    Journal: J AOAC Int; 2015 Jun 24; ():. PubMed ID: 26111082.
    Abstract:
    AOAC First Action Method 2011.19: Chromium, Selenium, and Molybdenum in Infant Formula and Adult Nutritional Products, was collaboratively studied. This method employs microwave digestion of samples with nitric acid, hydrogen peroxide, and internal standard followed by simultaneous detection of the elements by an inductively coupled plasma mass spectrometer (ICP-MS) instrument equipped with a collision/reaction cell. During this collaborative study, nine laboratories from four different countries, using seven different models of ICP-MS instruments, analyzed blind duplicates of seven infant, pediatric, and adult nutritional formulas. One laboratory's set of data was rejected in its entirety. The method demonstrated acceptable repeatability and reproducibility and met The Stakeholder Panel on Infant Formula and Adult Nutritionals (SPIFAN) standard method performance requirements (SMPR) for almost all of the matrices analyzed. The Cr, Mo, and Se SPIFAN requirement for repeatability was 5% RSD. The SMPR called for a reproducibility of 15% RSD in products for ultratrace element concentrations above the targeted limit of quantitation of 20 μg/kg Cr/Mo and 10 μg/kg Se (as ready-to-feed). During this collaborative study, repeatability relative standard deviation ranged from 1.0%-7.0% and reproducibility relative standard deviation ranged from 2.5-13.4% across all three ultratrace elements.
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