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  • Title: Trypanocidal Activity of Long Chain Diamines and Aminoalcohols.
    Author: Legarda-Ceballos AL, del Olmo E, López-Abán J, Escarcena R, Bustos LA, Fonseca-Berzal C, Gómez-Barrio A, Dib JC, San Feliciano A, Muro A.
    Journal: Molecules; 2015 Jun 23; 20(6):11554-68. PubMed ID: 26111182.
    Abstract:
    Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0-6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC50 = 0.6 µM), with a selectivity index of 54.
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