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  • Title: Management of intestinal bleeding with single-dose cyclophosphamide in Henoch-Schönlein purpura.
    Author: Uluca Ü, Ece A, Şen V, Yel S, Tan İ, Karabel D.
    Journal: Pediatr Int; 2015 Jun; 57(3):498-500. PubMed ID: 26113318.
    Abstract:
    In these case series, we report on six children (3 girls, 3 boys) aged 5-13 years with Henoch-Schönlein purpura (HSP) who developed severe gastrointestinal (GI) bleeding resistant to both 2 mg/kg or pulse (10-30 mg/kg) i.v. methylprednisolone. All patients responded to single-dose (500 mg/m(2) ) i.v. cyclophosphamide (CPA) and none of them developed new GI bleeding after CPA treatment. No patients required surgical intervention. Single high-dose CPA may be beneficial in HSP with severe GI involvement, in which bleeding is non-responsive to high-dose steroids.
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