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  • Title: [A cell population analysis of the initial period of hepatocyte proliferation in the regenerating mouse liver].
    Author: Miliutina NA.
    Journal: Biull Eksp Biol Med; 1989 Sep; 108(9):359-61. PubMed ID: 2611401.
    Abstract:
    Morphological autoradiography was used to determine the hepatocyte percentage in the regenerating liver of mice in S-, G-, M-, post-M phases at various times after partial hepatectomy, namely at 24, 30, 36 and 42 hours. The total number of cells in the above mentioned phases turned out to be very little at 24 and 30 hours. At 36 h., the percentage of cells in S phase (labelled nuclei) as well as in G2 phase (unlabelled morphologically obvious premitotic nuclei) appeared to be high. The two alternative explanation of G2 hepatocytes emerging at 36 hours were verified to find out if they are a) that is called "a reserved G2 population", or b) a population characterized by a shorter (down to 2 or 3 h) time of S phase.
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