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  • Title: The synthesis of an active derivative of cyclomaltoheptaose for the hydrolysis of esters and the formation of amide bonds.
    Author: Ekberg B, Andersson LI, Mosbach K.
    Journal: Carbohydr Res; 1989 Oct 23; 192():111-7. PubMed ID: 2611774.
    Abstract:
    The synthesis is described of a derivative of cyclomaltoheptaose (beta-cyclodextrin) to which the tripeptide Ser-His-Asp, the catalytic triad found in chymotrypsin, has been coupled. The derivative enhanced the rates of hydrolysis of activated esters, as measured by the release of p-nitrophenol, and the formation of amine bonds.
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