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  • Title: Synthesis and pharmacological evaluation of N-substituted 4,6-diaryl-3-pyridazinones as analgesic, antiinflammatory and antipyretic agents.
    Author: Rubat C, Coudert P, Tronche P, Bastide J, Bastide P, Privat AM.
    Journal: Chem Pharm Bull (Tokyo); 1989 Oct; 37(10):2832-5. PubMed ID: 2611945.
    Abstract:
    The synthesis and the pharmacological evaluation of 19 new 4,6-diaryl-3-pyridazinones are reported. All compounds were screened for analgesic, antiinflammatory and antipyretic activities. Introduction of an arylpiperazinomethyl moiety in the 2-position of the pyridazinone ring resulted in the most potent activities. Compounds 2a, 2b, 2h and 2i exhibited a higher analgesic activity than did aspirin or noramidopyrine in the hot plate test.
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