These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Osteoprotegerin polymorphisms in Chinese Han patients with rheumatoid arthritis.
    Author: Ye XH, Cheng JL, Liu RP.
    Journal: Genet Mol Res; 2015 Jun 12; 14(2):6569-77. PubMed ID: 26125863.
    Abstract:
    In order to investigate the association between osteoprotegerin (OPG) gene polymorphisms and rheumatoid arthritis (RA), we studied OPG rs3102735 T/C and rs2073618 G/C polymorphisms in a Chinese Han population comprising 574 patients with RA and 804 controls. Genotyping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was conducted. Our data indicated that OPG rs3102735 T/C and rs2073618 G/C polymorphisms were not associated with the risk of RA. However, among older patients (≥55 years), patients with the OPG rs3102735 TC (TC vs TT: OR = 0.68, 95%CI = 0.49‑0.96, P = 0.029) and TC/CC (TC+CC vs TT: OR = 0.69, 95%CI = 0.49‑0.96, P = 0.026) genotypes showed a significantly lower risk of RA than patients with the TT genotype, while patients with the OPG rs2073618 GC (GC vs GG: OR = 1.53, 95%CI = 1.13‑2.07, P = 0.006) and GC/CC (GC+CC vs GG: OR = 1.43, 95%CI = 1.07‑1.92, P = 0.015) genotypes showed a significantly higher risk of RA than patients with the GG genotype. We also found a significantly increased risk of RA associated with the OPG rs2073618 GC (GC vs GG: OR = 1.44, 95%CI = 1.07‑1.93, P = 0.018) and GC/CC (GC+CC vs GG: OR = 1.39, 95%CI = 1.04‑1.86, P = 0.024) genotypes among functional class III+IV patients. Our results were obtained from only a moderate-sized sample and, thus, a larger study with a more diverse ethnic population is needed to confirm these results.
    [Abstract] [Full Text] [Related] [New Search]