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  • Title: Cytosine-type nucleosides from marine-derived Streptomyces rochei 06CM016.
    Author: Aksoy SÇ, Uzel A, Bedir E.
    Journal: J Antibiot (Tokyo); 2016 Jan; 69(1):51-6. PubMed ID: 26126744.
    Abstract:
    Rocheicoside A (3), a nucleoside analog possessing a novel 5-(hydroxymethyl)-5-methylimidazolidin-4-one substructure, was isolated from marine-derived actinomycete Streptomyces rochei 06CM016, together with a new (4) and three known compounds. Structures of the new metabolites were elucidated by one-dimensional ((1)H and (13)C) and 2D NMR (COSY, HMQC and HMBC) and HR-TOF-MS analyses. All the metabolites exhibited significant antimicrobial activity. A plausible mechanism was proposed for compound 3's formation from amicetin.
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