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  • Title: Synthesis of Amathaspiramides by Aminocyanation of Enoates.
    Author: O'Connor M, Sun C, Lee D.
    Journal: Angew Chem Int Ed Engl; 2015 Aug 17; 54(34):9963-6. PubMed ID: 26130161.
    Abstract:
    Concise routes for the total and formal syntheses of the amathaspiramides were developed through a formal [3+2] cycloaddition between lithium(trimethylsilyl)diazomethane and α,β-unsaturated esters. The effectiveness of this new cycloaddition for the construction of Δ(2)-pyrazolines containing a α-tert-alkylamino carbon center and subsequent facile protonolytic N-N bond cleavage allows the synthesis of a key intermediate of the amathaspiramides and other α,α-disubstituted amino acid derivatives.
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