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  • Title: Relationship between IL-27 gene polymorphism and susceptibility of rheumatoid arthritis in Chinese Han population.
    Author: Yan J, Shang X, Rong X.
    Journal: Int J Clin Exp Med; 2015; 8(4):6262-6. PubMed ID: 26131236.
    Abstract:
    OBJECTIVE: To investigate the relationship between IL-27 gene polymorphism and the susceptibility of rheumatoid arthritis (RA) in a Chinese Hans population. METHODS: 310 RA patients and 310 healthy controls were examined in this study. Polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) technique was used in the detection of the genotype in three loci of IL-27 gene (-964A/G, 2905T/G, and 4730T/C). We compared genotype and allele frequency and distribution of these two groups. RESULTS: The genotype distribution of the case group and the control group were all in accordance with Hardy-Weinberg equilibrium (P>0.05). The difference of genotype and allele frequencies of three loci between these two groups showed no statistically significant (P>0.05). But the frequencies of G-T-C haplotype was significantly higher in the case group than in the control group, the difference showed statistically significant (OR=2.001, 95% CI: 1.121~3.573; P=0.0170). G-T-T haplotype in case group was significantly lower than that in the control group, the difference showed statistically significant (OR=0.715, 95% CI: 0.527~0.970, P=0.030). CONCLUSION: In Chinese Hans population, IL-27 gene haplotypes were correlated with the risk of RA. G-T-C haplotype was the risk factors for the incidence of RA, but G-T-T haplotype maybe was the protective factor of RA.
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