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  • Title: The production of highly specific anti-testosterone antisera using acid-treated bacteria as immunogenic carrier.
    Author: Cilliers JM, Stindt HW, Bellstedt DU.
    Journal: Immunol Invest; 1989; 18(9-10):1035-48. PubMed ID: 2613285.
    Abstract:
    A novel and effective procedure for the production of highly specific anti-testosterone antibodies is described. It involved pretreatment of experimental animals with tolerogens followed by immunization with conjugates of testosterone covalently linked to acid-treated Salmonella minnesota R595 bacteria as immunogenic carriers. Antibodies elicited by this procedure showed minimal cross-reactivity towards 5 alpha-dihydrotestosterone and some of them were successfully used in radioimmunoassays for the determination of serum testosterone levels, even without the need for prior extraction.
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