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  • Title: Selective killing of human monocytes by an immunotoxin containing partially denatured mistletoe lectin I.
    Author: Schütt C, Pfüller U, Siegl E, Walzel H, Franz H.
    Journal: Int J Immunopharmacol; 1989; 11(8):977-80. PubMed ID: 2613400.
    Abstract:
    The in vitro activity of an immunotoxin (IT) prepared by conjugating the monocyte specific RoMo-1 monoclonal antibody and partially inactivated Mistletoe lectin I (dMLI) containing inactivated B chain has been initially characterized. It is shown that while not affecting other mononuclear cells viability, this IT is capable of selectively destroying human monocytes after 24 h exposure thus resulting in the abrogation of monocyte support for PHA reactivity in mononuclear cell preparations. Therefore it seems to be possible to use this non-sugar binding holotoxin for immunotoxin preparation.
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