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  • Title: Asymmetric synthesis of optically active methyl-2-benzamido-methyl-3-hydroxy-butyrate by robust short-chain alcohol dehydrogenases from Burkholderia gladioli.
    Author: Chen X, Liu ZQ, Huang JF, Lin CP, Zheng YG.
    Journal: Chem Commun (Camb); 2015 Aug 07; 51(61):12328-31. PubMed ID: 26140446.
    Abstract:
    Three short-chain alcohol dehydrogenases from Burkholderia gladioli were discovered for their great potential in the dynamic kinetic asymmetric transformation of methyl 2-benzamido-methyl-3-oxobutanoate, and their screening against varied organic solvents and substrates. This is the first report of recombinant enzymes capable of achieving this reaction with the highest enantio- and diastereo-selectivity.
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