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  • Title: Design of controlled release systems for THEDES-Therapeutic deep eutectic solvents, using supercritical fluid technology.
    Author: Aroso IM, Craveiro R, Rocha Â, Dionísio M, Barreiros S, Reis RL, Paiva A, Duarte AR.
    Journal: Int J Pharm; 2015 Aug 15; 492(1-2):73-9. PubMed ID: 26142248.
    Abstract:
    Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC). A controlled drug delivery system was developed by impregnating a starch:poly-ϵ-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt%), after supercritical fluid sintering at 20 MPa and 50 °C. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT). Drug release studies were carried out in a phosphate buffered saline. The results obtained provide important clues for the development of carriers for the sustainable delivery of bioactive compounds.
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