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  • Title: Regional cerebral blood flow by SPECT imaging in Sturge-Weber disease: an aid for diagnosis.
    Author: Chiron C, Raynaud C, Tzourio N, Diebler C, Dulac O, Zilbovicius M, Syrota A.
    Journal: J Neurol Neurosurg Psychiatry; 1989 Dec; 52(12):1402-9. PubMed ID: 2614436.
    Abstract:
    Regional cerebral blood flow (rCBF) was studied using SPECT (single photon emission computed tomography) with 133-Xenon in 13 patients with confirmed Sturge-Weber disease, aged 9 months to 18 years. CT scan, performed at the same time, showed evident cerebral angioma in 10 but not in three. A marked hypoperfused area was found in all patients, ranging from -32% to -72% and of the same location as the CT signs. The hypoperfusion seems to result from post ictal phenomenon as well as from chronic ischaemia. SPECT imaging is therefore a sensitive method for visualising intracranial angioma in Sturge-Weber disease and it provides an aid for diagnosis when a CT scan is not reliable.
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