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  • Title: [Pathogenesis of pulmonary involvement in HTLV-I-associated myelopathy (HAM): studies on T-cell function].
    Author: Sugimoto M, Matsumoto M, Nakashima H, Imamura F, Kawano O, Imamura S, Fukuda Y, Ando M, Araki S.
    Journal: Nihon Kyobu Shikkan Gakkai Zasshi; 1989 Oct; 27(10):1198-203. PubMed ID: 2615072.
    Abstract:
    It has been shown that there are pulmonary involvements in patients with HTLV-1-associated myelopathy (HAM). Pulmonary lesions found in HAM are characterized by T-lymphocytosis and increased levels of soluble IL-2 receptor in bronchoalveolar lavage fluid. Peripheral blood lymphocytes from HAM patients proliferated spontaneously when cultured in vitro. Lymphocytes proliferated were positive for CD3 and HLA-DR staining. There were CD4+ cells and CD8+ cells in proliferating T-lymphocytes 5 days after cultivation. Culture supernatants of proliferating cells showed an increased soluble IL-2 receptor. These results suggest that activated T-cells play an important role in developing pulmonary lesions in HAM.
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