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  • Title: [A case of the bare lymphocyte syndrome with clinical manifestations of diffuse panbronchiolitis].
    Author: Sugiyama Y, Kudoh S, Kitamura S.
    Journal: Nihon Kyobu Shikkan Gakkai Zasshi; 1989 Aug; 27(8):980-3. PubMed ID: 2615115.
    Abstract:
    Touraine et al reported some cases lacking HLA-class I antigens on the cell surface of their lymphocytes as "Bare lymphocyte syndrome" (BLS). Recently we experienced a case of BLS the clinical features of which are very similar to those of diffuse panbronchiolitis (DPB). Namely, she had chronic pansinusitis, diffuse nodular shadows on her chest X-ray film, obstructive impairment of pulmonary function tests and continuous increase of cold hemagglutinin titer. The pathogenesis of DPB is not confirmed. However, this case and other cases with sino-bronchial syndrome suggest that patients with DPB may have some immunodeficiencies. In addition the immunosuppressive action of erythromycin and its effectiveness on DPB were interesting. From these points of view, we discussed the relationship between this case and DPB, and the pathogenesis of DPB.
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