These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Boron-Catalyzed Silylative Reduction of Nitriles in Accessing Primary Amines and Imines.
    Author: Gandhamsetty N, Jeong J, Park J, Park S, Chang S.
    Journal: J Org Chem; 2015 Jul 17; 80(14):7281-7. PubMed ID: 26152758.
    Abstract:
    Silylative reduction of nitriles was studied under transition metal-free conditions by using B(C6F5)3 as a catalyst with hydrosilanes as a reductant. Alkyl and (hetero)aryl nitriles were efficiently converted to primary amines or imines under mild conditions. The choice of silanes was found to determine the selectivity: while a full reduction of nitriles was highly facile, the use of sterically bulky silanes allowed for the partial reduction leading to N-silylimines.
    [Abstract] [Full Text] [Related] [New Search]