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  • Title: Enhancing the efficiency of sortase-mediated ligations through nickel-peptide complex formation.
    Author: David Row R, Roark TJ, Philip MC, Perkins LL, Antos JM.
    Journal: Chem Commun (Camb); 2015 Aug 14; 51(63):12548-51. PubMed ID: 26152789.
    Abstract:
    A modified sortase A recognition motif containing a masked Ni(2+)-binding peptide was employed to boost the efficiency of sortase-catalyzed ligation reactions. Deactivation of the Ni(2+)-binding peptide using a Ni(2+) additive improved reaction performance at low to equimolar ratios of the glycine amine nucleophile and sortase substrate. The success of this approach was demonstrated with both peptide and protein substrates.
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