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  • Title: [Clinical use of growth hormone and clonidine in growth disorders].
    Author: Vinci VS, Masotti G, Citro G, DeMarca S, Quaglia C.
    Journal: Medicina (Firenze); 1989; 9(3):288-91. PubMed ID: 2615602.
    Abstract:
    The aim of this study was to investigate the effects of the recombinant human growth hormone and of the alpha-2 adrenergic agonist clonidine in three groups of prepuberal children with growth disorders. Three children with GH-deficiency were treated with 0.5 U kg/week i.m. of recombinant growth hormone; 13 children (7 with constitutional delay of growth and 6 with familiar short stature) were treated with 0.08 mg/m2/die per os of clonidine. The results confirmed the growth promoting effect of GH in GH-deficiency. Clonidine restored GH-secretion in children with constitutional delay, but had a very poor or no effect in familiar short children.
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