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  • Title: Rosette-forming glioneuronal tumor originating in the hypothalamus.
    Author: Yamamoto T, Matsubara T, Satomi K, Sakamoto N, Matsuda M, Muroi A, Ishikawa E, Akutsu H, Nakai K, Matsumura A.
    Journal: Brain Tumor Pathol; 2015 Oct; 32(4):291-6. PubMed ID: 26156565.
    Abstract:
    Rosette-forming glioneuronal tumors (RGNT) of the fourth ventricle are slow-growing tumors that primarily involve the fourth ventricular region. We here report the first patient, an 8-year-old girl, with an RGNT originating in the hypothalamus and manifesting with precocious puberty. After partial removal, the remaining tumor showed rapid enlargement, and the pathologic diagnosis at the second surgery revealed histopathologic features similar to those found in the initial samples, including biphasic patterns of neurocytic rosettes and GFAP-stained astrocytic components. These tumor cells had mildly atypical nuclei; however, mitotic figures and necrosis were absent. Eosinophilic granular bodies and a glomeruloid vasculature were found, but Rosenthal fibers were absent. The Ki-67 proliferative index was 3.5 % (vs 1.1 % at the initial surgery). No recurrence was recorded during the 3-year period after the proton radiotherapy.
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