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  • Title: [Cyclosporin A in severe aplastic anemia in children].
    Author: Lackner H, Urban C, Kaulfersch W, Slavc I, Gamillscheg A, Hauer C.
    Journal: Padiatr Padol; 1989; 24(4):313-20. PubMed ID: 2616176.
    Abstract:
    Severe aplastic anemia should be treated with bone marrow transplantation if possible. Various clinical and experimental data support the view that the major pathogenetic defect in SAA is a dysregulated cellular immune response which in turn has a negative effect upon hematopoiesis. Therefore a large percentage of patients react favorably to treatment with immunosuppressive agents as antithymocyte globulin and high-dose methylprednisolone. Data concerning the efficiency of Cyclosporine A treatment are limited until now. We present in this report our own experience with Cyclosporine A treatment in three children with severe aplastic anemia who lack a bone marrow donor. Included is also a review of the present therapeutic possibilities.
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