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  • Title: Colony formation of CFU-MK and other hemopoietic progenitors in patients with acute non-lymphoblastic leukemia at diagnosis and following complete remission.
    Author: Chen Y, Li P, Lin B, Zhang G, Ruan C.
    Journal: Nouv Rev Fr Hematol (1978); 1989; 31(3):183-6. PubMed ID: 2616265.
    Abstract:
    Blood and marrow mononuclear cells were cultured in methylcellulose and plasma clot. In patients with acute non-lymphoblastic leukemia (ANLL) at diagnosis, marrow multipotential progenitors (CFU-Mix), megakaryocyte progenitors (CFU-MK) and granulocyte-monocyte progenitors (CFU-GM) were reduced or undetectable (all p less than 0.01). Two to 4 weeks after completion of induction therapy, marrow CFU-Mix returned to normal level (p greater than 0.05), CFU-MK and CFU-GM reached levels significantly higher than normal controls (both p less than 0.01), and circulating CFU-Mix, CFU-MK and CFU-GM were about 3, 6 and 6 times normal controls respectively (all p less than 0.01). During maintenance therapy CFU-Mix remained in low normal range (p greater than 0.05) and CFU-MK and CFU-GM were significantly reduced (both p less than 0.01). In patients at relapse CFU-Mix was undetectable (p less than 0.01) and CFU-MK and CFU-GM were undetectable or reduced (both p less than 0.01). The percentages of CFU-MK and CFU-GM in cell cycle S-phase as analysed by ara-c suicide technique were 51.4 +/- 5.8 and 52.3 +/- 2.3 two weeks after the completion of induction therapy, and 61.1 +/- 7.9 and 53.8 +/- 8.7 during maintenance therapy, all significantly higher than normal controls (all p less than 0.01). Our results suggest that chemotherapy may not result in severe damage to CFU-Mix, and that cell culture technique may be helpful in assessing prognosis.
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