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  • Title: Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue.
    Author: Bae J, McNamara LE, Nael MA, Mahdi F, Doerksen RJ, Bidwell GL, Hammer NI, Jo S.
    Journal: Chem Commun (Camb); 2015 Aug 18; 51(64):12787-90. PubMed ID: 26165999.
    Abstract:
    A near-infrared fluorescent probe based on methylene blue (p-NBMB) was developed for the detection of nitroreductase. Conjugating methylene blue with a p-nitrobenzyl moiety enables it to be activated by nitroreductase-catalyzed 1,6-elimination, resulting in the release of an active methylene blue fluorophore.
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