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  • Title: [The stimulating effect of preliminary irradiation of the hematopoietic stroma with small doses on the content of hematopoietic stem cells in the bone marrow in vivo and in a long-term culture system].
    Author: Lebedev VG, Romashko OO, Moroz BB.
    Journal: Radiobiologiia; 1989; 29(6):782-6. PubMed ID: 2616755.
    Abstract:
    Preirradiation of mouse recipients with a dose of 1-2 Gy 24 and 48 h before lethal irradiation (8 Gy) made CFUs content of femur increase upon transplantation of bone marrow from exposed and intact donors. The same was with the long-term bone marrow culture: preirradiation of a stromal sublayer increased the number of CFUs in the transplanted bone marrow preirradiated with 6 Gy radiation. Retransplantation of bone marrow to irradiated donors after 5 day cultivation, a sublayer being activated, increased the number of CFUs in the femur in comparison with donors which were injected with the bone marrow from the culture without activation of the sublayer by low-level radiation.
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