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  • Title: Synthesis and Comparative Study of Anti-Adenoviral Activity of 6-Azacytidine and Its Analogues.
    Author: Alexeeva I, Nosach L, Palchykovska L, Usenko L, Povnitsa O.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2015; 34(8):565-78. PubMed ID: 26167665.
    Abstract:
    This paper presents the results of synthesis and study of cytotoxicity and the anti-adenoviral activity of new N4-derivatives of 6-azacytidine and its α-L-glycopyranosyl analogues obtained by the simplified one-pot version of the silyl condensation method. The resulting acylated 4-methylmercapto-1,2,4-triazin-3(2Н)-one glycosides then underwent the amination and/or ammonolysis to provide 6-azacytidine glycoside analogues (2-6, 12, 15, 17) and compounds with modifications at both base and sugar fragments (11, 15). The evaluation of cytotoxicity and antiviral activity of new compounds against AdV5 showed high selectivity indexes for N4-methyl-6-azacytidine (2) and N,O-tetraacetyl-6-azacytidine (8). High anti-adenoviral activity of N4-methyl-6-azacytidine as well as very low cytotoxicity may suggest its further investigation as potential compound for the therapy of AdV infection.
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