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  • Title: Clinical significance of the prenatal double bubble sign - single institution experience.
    Author: Kucińska-Chahwan A, Posiewka A, Bijok J, Jakiel G, Roszkowski T.
    Journal: Prenat Diagn; 2015 Nov; 35(11):1093-6. PubMed ID: 26175315.
    Abstract:
    OBJECTIVE: The objective of this study is to determine the risk of aneuploidy, associated structural anomalies, and pregnancy outcome in the presence of prenatal double bubble sign detection. METHOD: We have performed a retrospective study on ultrasound reports and pregnancy outcomes in 42 fetuses with double bubble sign examined in our ultrasound department between 1998 and 2013. RESULTS: Additional major defects or aneuploidy markers were present in 24 fetuses. Chromosomal abnormalities occurred in 21 cases. There were 35 live births; two pregnancies ended in intrauterine fetal demise; five patients opted for termination of pregnancy because of additional anomalies or abnormal karyotype. Postnatal or postmortem verification revealed duodenal obstruction secondary to intrinsic or extrinsic cause in 40 cases; in one case, proximal jejunal atresia was diagnosed, and one neonate had normal bowel. CONCLUSIONS: Sonographic double bubble sign is associated with a significant rate of major anatomic defects, abnormal karyotype, and unfavorable pregnancy outcome. It is strongly indicative of duodenal obstruction.
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