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  • Title: Unusual presentation of Gilbert disease with high levels of unconjugated bilirubin. Report of two cases.
    Author: Flores-Villalba E, Rodriguez-Montalvo C, Bosques-Padilla F, Arredondo-Saldaña G, Zertuche-Maldonado T, Torre-Flores L.
    Journal: Rev Esp Enferm Dig; 2016 Apr; 108(4):228-30. PubMed ID: 26181050.
    Abstract:
    Gilbert's syndrome is a benign condition characterized by asymptomatic sporadic episodes of jaundice, due to a mild unconjugated hyperbilirubinemia caused by a deficiency in bilirubin glucoronidation. Under certain physiologic or pathologic events bilirubin level rises but according to literature it does not reach out more than 3 mg/dl. We report 2 cases of Gilbert's syndrome, genetically tested, which presented with bilirubin levels above 6 mg/dl without any trigger or coexisting condition. In conclusion, bilirubin levels higher than 6 mg/dL in Gilbert syndrome are rare, hemolytic and other metabolism diseases must be ruled out, and genetic testing may be necessary in some cases.
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