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  • Title: Asymmetric Total Synthesis of Propindilactone G.
    Author: You L, Liang XT, Xu LM, Wang YF, Zhang JJ, Su Q, Li YH, Zhang B, Yang SL, Chen JH, Yang Z.
    Journal: J Am Chem Soc; 2015 Aug 19; 137(32):10120-3. PubMed ID: 26181605.
    Abstract:
    A concise total synthesis of (+)-propindilactone G, a nortriterpenoid isolated from the stems of Schisandra propinqua var. propinqua, has been achieved for the first time. The key steps of the synthesis include an asymmetric Diels-Alder reaction, a Pauson-Khand reaction, a Pd-catalyzed reductive hydrogenolysis reaction, and an oxidative heterocoupling reaction. These reactions enabled the synthesis of (+)-propindilactone G in only 20 steps. As a consequence of our synthetic studies, the structure of (+)-propindilactone G has been revised.
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