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  • Title: Tubeimoside-1 inhibits the proliferation and activation of mouse T lymphocytes through signal transduction pathways.
    Author: Huang Y, Ren M, Xiong Y, Wang T, Chen H, Deng X, Lu J.
    Journal: Immunopharmacol Immunotoxicol; 2015; 37(4):366-74. PubMed ID: 26181650.
    Abstract:
    Tubeimoside-1 (TBMS1) is one of the important components in Bolbostemma paniculatum (Maxim.) Franque. In the study, its immunosuppressive effects on murine T lymphocyte responses were evaluated in vitro and in vivo. The data showed that TBMS1 inhibited ConA-induced T lymphocyte proliferation, decreased the ratio of CD4(+)/CD8(+), suppressed IL-2, IFN-γ, IL-4 and IL-6 production and mRNA expression, down-regulate activation of NF-κB, NFAT2 and AP-1 signal transduction pathways in vitro. In addition, administration of TBMS1 significantly inhibited T cell-mediated DTH response in vivo. These findings indicated that TBMS1 inhibits the proliferation and activation of T lymphocytes in mice.
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