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  • Title: [Problem of typological differentiation of the defect in symptom-poor schizophrenia (clinico-genetic correlations)].
    Author: Lu'kianova LL.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1989; 89(10):92-8. PubMed ID: 2618242.
    Abstract:
    The clinico-genealogical method with the use of a genetic-mathematic analysis was applied to examine 85 probands with pure-symptoms schizophrenia (221 relations of grade I kinship). Schizophrenia with the defect of the simple deficiency type was established to be genetically, similar to schizophrenia with a psychopath-like defect characterized by veschroben. Different types of familial predisposition by the type of schizophrenia+ and by the spectrum of psychopathies were found to correspond to the studied variants of pure-symptoms schizophrenia. These correlations were confirmed by the data of the genetic-correlation analysis. It is assumed that determination of the typological differences in the defect structure in pure-symptoms schizophrenia is under the control of constitutional and genetic factors.
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