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  • Title: Assessment of neuroregenerative effect of dihydrotestosterone, on peripheral nerve regeneration using allografts: a rat sciatic nerve model.
    Author: Karegar M, Mohammadi R.
    Journal: Neurol Res; 2015 Oct; 37(10):908-15. PubMed ID: 26187472.
    Abstract:
    OBJECTIVES: Effects of dihydrotestosterone on nerve allograft were studied in a rat sciatic nerve model. METHODS: 30 healthy male white Wistar rats were castrated and randomised into three experimental groups (n = 10): Normal control group (NC), autograft group (AUTO), allograft group (ALLO) and dihydrotestosterone-treated group (ALLO/DHT). In NC group, left sciatic nerve was exposed and left intact. In autograft group, a segment of sciatic nerve was transected and reimplanted reversely. In the ALLO group, the left sciatic nerve was exposed and transected where a 10-mm segment was excised. The same procedure was performed in the ALLO/DHT group. The harvested nerves of the rats of ALLO group were served as allograft for ALLO/DHT group and vice versa. The NC, AUTO and ALLO groups received 300 μl phosphate buffered saline (PBS) intraperitoneally once a day for 1 week and the ALLO/DHT group received 300 μl DHT (1 mg/kg/day) interaperitoneally once a day for 1 week. RESULTS: The results showed earlier regeneration of axons in ALLO/DHT than in ALLO group (P < 0.05). Histomorphometic and immunohistochemical studies also showed earlier regeneration of axons in ALLO/DHT than in ALLO group (P < 0.05). DISCUSSIONS: Administration of DHT could accelerate functional recovery after nerve allografting in sciatic nerve and may have implications in clinical practice.
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