These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of adenosine on melatonin and norepinephrine release in rat pineal explants.
    Author: Vacas MI, Sarmiento MI, Pereyra EN, Cardinali DP.
    Journal: Acta Physiol Pharmacol Latinoam; 1989; 39(2):189-95. PubMed ID: 2618756.
    Abstract:
    To study adenosine effect on melatonin production, rat pineal explants were incubated for 6 h with 10(-4) M adenosine or 2-chloroadenosine in the presence or absence of 5 x 10(-5) M norepinephrine (NE). Melatonin content in pineal gland and medium was measured by RIA. Both adenosine and 2-chloroadenosine increased melatonin production rate by 3-4-fold, and augmented NE stimulation by 30-40%. Addition of adenosine deaminase prior to NE reduced stimulated melatonin release by 40-46%. 2-Chloroadenosine counteracted the inhibition of NE response given by adenosine deaminase. Either adenosine or its A1 receptor agonist cyclohexyl adenosine (CHA) decreased by 20-22% 3H-transmitter release induced by a K+ depolarizing stimulus in rat pineal incubated with 3H-NE. These results suggest that adenosine affects both pre- and postsynaptic pineal mechanisms.
    [Abstract] [Full Text] [Related] [New Search]