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  • Title: [The postoperative treatment of hypertension with urapidil in patients with cerebrovascular aneurysms].
    Author: Hussein S, Seifert V.
    Journal: Anasth Intensivther Notfallmed; 1989 Dec; 24(6):373-6. PubMed ID: 2618993.
    Abstract:
    In 10 patients with subarachnoidal haemorrhage and an identified aneurysm the blood pressure was reduced intraoperatively by means of sodium nitroprusside. Arterial and intracranial pressures were continuously recorded in all patients. In 9 patients a rebound phenomenon occurred as manifested by an increase in blood pressure during the postoperative phase after sodium nitroprusside infusion. Rapid reduction of blood pressure was achieved in all patients by a bolus injection of initially 25 mg Urapidil. Undesirably low blood pressure values were seen in a patient. The continuously recorded intracranial pressure remained in the normal range in all patients. Blood pressure reduction by means of Urapidil does not exercise any influence on intracranial pressure, in contrast to blood pressure reduction via nitroglycerin, sodium nitroprusside, dihydroalacin and diazoxide.
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