These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: L-alphacetylmethadol (LAAM) effects on cardiac muscarinic receptors.
    Author: Langley AE.
    Journal: Arch Int Pharmacodyn Ther; 1989; 300():140-8. PubMed ID: 2619421.
    Abstract:
    Chronic treatment with l-alphacetylmethadol (LAAM) reduced the number of myocardial muscarinic receptors measured by either antagonist binding with [3H]-quinuclidinyl benzilate ([3H]QNB) or agonist binding with [3H]-oxotremorine ([3H]OXO). The affinities of these binding sites for either [3H]QNB or [3H]OXO were unchanged by LAAM treatment. The ability of LAAM to antagonize the binding of [3H]QNB (125 pM) or [3H]OXO (8 nM) to myocardial membranes was tested. The measured affinity constant for LAAM was more than 200 times higher than atropine and 6 times lower than pilocarpine vs [3H]OXO binding, while the affinity constant for LAAM vs [3H]OXO was 1500 times higher than atropine, 30 times higher than methacholine but only 1.5 times higher than pilocarpine vs [3H]OXO binding. In isolated rat hearts, LAAM produced a concentration-dependent decrease in resting heart rate which was partially sensitive to inhibition by atropine. These data indicate that LAAM may act as a weak or partial agonist at myocardial muscarinic receptor sites.
    [Abstract] [Full Text] [Related] [New Search]