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  • Title: Pharmacokinetics of dipyridamole-beta-cyclodextrin complex in dogs.
    Author: Stracciari GL, Malvisi J, Anfossi P, Fregnan GB.
    Journal: Arch Int Pharmacodyn Ther; 1989; 300():7-13. PubMed ID: 2619427.
    Abstract:
    Plasma concentrations and urinary and fecal excretion of intact dipyridamole were followed in dogs after oral administration of dipyridamole-beta-cyclodextrin complex (dip-beta-CD) (capsules containing 37.5 and 75 mg of active principle), of commercial dipyridamole and of dipyridamole. HCl (tablets and capsules of 75 mg of active principle, respectively), according to a crossover design. Dip-beta-CD afforded significantly shorter lag-times, higher Cmax, smaller interindividual variations of plasma concentrations and greater urinary excretion than the other two preparations, as a consequence of a better bioavailability of the former one. This amelioration seems to be due not only to an increased wettability and water solubility of the product, but also to a finer molecular dispersion in the gastrointestinal fluids which favors the contact of dipyridamole with a greater absorption surface.
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