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  • Title: ATP Hydrolysis in the RecA-DNA Filament Promotes Structural Changes at the Protein-DNA Interface.
    Author: Reymer A, Babik S, Takahashi M, Nordén B, Beke-Somfai T.
    Journal: Biochemistry; 2015 Aug 04; 54(30):4579-82. PubMed ID: 26196253.
    Abstract:
    To address the mechanistic roles of ATP hydrolysis in RecA-promoted strand exchange reaction in homologous recombination, quantum mechanical calculations are performed on key parts of the RecA-DNA complex. We find that ATP hydrolysis may induce changes at the protein-DNA interface, resulting in the rearrangement of the hydrogen bond network connecting the ATP and the DNA binding sites.
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