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  • Title: Enhanced formation of lipid peroxides might contribute to the high sensitivity of spontaneously hypertensive rats towards isoproterenol-induced myocardial damage.
    Author: Papies B, Schimke I, Moritz V.
    Journal: Biomed Biochim Acta; 1989; 48(9):681-7. PubMed ID: 2619736.
    Abstract:
    Lipid peroxidation as well as enzyme and isoenzyme activities in heart and blood plasma were investigated in 8- and 20-week-old SHR after administration of 40 mg/kg body weight isoproterenol in comparison to WKY rats in order to examine the susceptibility of the hearts of hypertensive animals towards catecholamine-induced damage. The mortality of SHR after isoproterenol application was distinctly higher as compared with WKY rats. SHR showed significantly higher concentrations of lipid peroxides in the myocardium after isoproterenol. Distinctly higher plasma activities of CK, isoenzymes of LDH and ASAT as well as markedly lower CK activities in the myocardium point to an enhanced sensitivity of SHR to catecholamine-induced damage. The results obtained in this study favour the suggestion that an exaggerated nonenzymatic and perhaps enzymatic formation of peroxidized lipids in the myocardium might contribute to this increased sensitivity.
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