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  • Title: Increase in glutathione disulfide level regulates the activity of microsomal glutathione S-transferase in rat liver.
    Author: Nishino H, Ito A.
    Journal: Biochem Int; 1989 Oct; 19(4):731-5. PubMed ID: 2619745.
    Abstract:
    Glutathione disulfide stimulates the activity of rat liver microsomal glutathione S-transferase 2-fold after incubation at 25 degrees C for 10 min. When the microsomes were incubated with the disulfide for over 20 min, the transferase activity increased to the same extent as in the case of N-ethylmaleimide (6-fold). Even in the presence of reduced glutathione, some enhancement of the transferase activity was observed. The data presented here are evidence that increase in glutathione disulfide level, e.g. by lipid peroxidation, on endoplasmic reticulum causes the upregulation of microsomal glutathione S-transferase activity.
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