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  • Title: Hypoglycaemic activity of carbothioamides and related 1,2,4-thiodiazolidines.
    Author: Chaubey M, Pandeya SN.
    Journal: Farmaco; 1989 Oct; 44(10):987-95. PubMed ID: 2619864.
    Abstract:
    N-[imino(ethyl ethylidine hydrazine)methyl]-N-aryl-2- amino-carbothioamidine hydrochlorides with ethylmethylketothiosemicarbazone in acetone medium at 0-5 degrees C. The carbothioamides were oxidized by H2O2 to 1,2,4-thiodiazolidine derivatives. The 4-Cl derivative in both the series was the most active hypoglycaemic agent. The compounds lowered mean blood sugar levels (MBSL) by 38.81% (compound 2, Table II) and 15.19% (compound 2, Table III) respectively after 24 hours of drug treatment. The compounds also showed antidiabetic activity in alloxan diabetic rats.
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