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  • Title: Characterization of l-Digitoxosyl-phenanthroviridin from Streptomyces venezuelae ISP5230.
    Author: Robertson AW, Martinez-Farina CF, Syvitski RT, Jakeman DL.
    Journal: J Nat Prod; 2015 Aug 28; 78(8):1942-8. PubMed ID: 26203536.
    Abstract:
    The jadomycin-derived compound l-digitoxosyl-phenanthroviridin was isolated from fermentations of Streptomyces venezuelae ISP5230 grown in nutrient-deficient media with l-lysine as the sole nitrogen source. Structural elucidation was accomplished using a combination of high-resolution MS, LC-MS/MS, and 1D- and 2D-NMR. The compound was evaluated against the National Cancer Institute (NCI) 60 human tumor cell line screen in both the one-dose and five-dose screens, and cytotoxicity was compared to a small library of jadomycin analogues to probe the structure-activity relationship.
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