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  • Title: Association study between reward dependence and a functional BDNF polymorphism in adult women offspring of alcohol-dependent probands.
    Author: Benzerouk F, Gierski F, Raucher-Chéné D, Ramoz N, Gorwood P, Kaladjian A, Limosin F.
    Journal: Psychiatr Genet; 2015 Oct; 25(5):208-11. PubMed ID: 26204172.
    Abstract:
    Thirty-five healthy adult women offspring of alcohol-dependent probands (AWOA) were compared with 63 healthy controls to test whether personality dimensions on the Temperament and Character Inventory questionnaire were associated with the brain-derived neurotrophic factor Val66Met polymorphism in offspring. We found a significantly lower reward dependence score in AWOA compared with the controls. The brain-derived neurotrophic factor Val66Met polymorphism may be involved in this difference as the lower reward dependence score was found only in AWOA carrying the Val allele.
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