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  • Title: Evaluation of bone mass in children and young adults with juvenile idiopathic arthritis.
    Author: Tang T, Tang X, Xu L, Huang Y, Zeng J, Li Q.
    Journal: Clin Exp Rheumatol; 2015; 33(5):758-64. PubMed ID: 26211456.
    Abstract:
    OBJECTIVES: To examine bone mineral density (BMD) in the spines of patients with juvenile idiopathic arthritis (JIA), and to identify the main predictors of spine BMD. METHODS: 160 patients with JIA (82 female, 78 male; median age, 8.7±3.9 years (range, 2.2-18.2 years)) who fulfilled the International League of Associations for Rheumatology (ILAR) criteria were enrolled. All subjects underwent an initial dual energy x-ray absorptiometry (DXA) scan of the lumbar spine, while 114 and 87 patients underwent a second and third scan, respectively. The data were compared with those obtained for 114 sex- and age-matched healthy controls. RESULTS: The DXA scans revealed that the JIA patients had a significant spine BMD deficit compared with control subjects (p<0.001). Longitudinal comparison of patients revealed no significant short-term improvement in the spine BMD. Spine BMD correlated with the age (p<0.05), subtype (p<0.05), and disease activity (p<0.01), BMI (p=0.001), glucocorticoid (GC) exposure (p< 0.05), methotrexate (MTX) therapy (p<0.05), and non-steroidal anti-inflammatory agents (NSAIDs) (p<0.05), erythrocyte sedimentation rate (ESR) (p<0.01), and C-reactive protein (CRP) levels (p<0.01). CONCLUSIONS: Patients with JIA have low bone mass, especially those in the polyarticular group >7 years old with higher disease activity.
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