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  • Title: CD68 acts as a major gateway for malaria sporozoite liver infection.
    Author: Cha SJ, Park K, Srinivasan P, Schindler CW, van Rooijen N, Stins M, Jacobs-Lorena M.
    Journal: J Exp Med; 2015 Aug 24; 212(9):1391-403. PubMed ID: 26216124.
    Abstract:
    After being delivered by the bite from an infected mosquito, Plasmodium sporozoites enter the blood circulation and infect the liver. Previous evidence suggests that Kupffer cells, a macrophage-like component of the liver blood vessel lining, are traversed by sporozoites to initiate liver invasion. However, the molecular determinants of sporozoite-Kupffer cell interactions are unknown. Understanding the molecular basis for this specific recognition may lead to novel therapeutic strategies to control malaria. Using a phage display library screen, we identified a peptide, P39, that strongly binds to the Kupffer cell surface and, importantly, inhibits sporozoite Kupffer cell entry. Furthermore, we determined that P39 binds to CD68, a putative receptor for sporozoite invasion of Kupffer cells that acts as a gateway for malaria infection of the liver.
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