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  • Title: A retrospective study of 40 cases of canine pyometra-metritis treated with prostaglandin F-2 alpha and broad-spectrum antibacterial drugs.
    Author: Gilbert RO, Nöthling JO, Oettle EE.
    Journal: J Reprod Fertil Suppl; 1989; 39():225-9. PubMed ID: 2621725.
    Abstract:
    Bitches with pyometra were treated with dinoprost, a prostaglandin F-2 alpha-THAM salt or luprostiol, a synthetic PG analogue and oral broad-spectrum antibacterial drugs. PGF-2 alpha treatment lasted 2-26 days and dosage varied from 26.8 to 258 micrograms/kg. Clinical cure from symptoms was achieved in 33/40 bitches. Of 14 bitches from which the owners opted to breed, 9 eventually produced litters. Long-term complications were anoestrus, recurrence of metritis, failure to conceive and abortion. One or more of these complications were recorded in 9 of 20 bitches for which long term information was available.
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